An important issue is addressed in the latest Trilead VM Explorer release 4.1.004
Trilead announced …
New support for ESX/ESXi 5.1 838463 – which keeps current with the latest changes but more importantly – Implementation of VMware’s workaround to avoid VDDK library issue, which could compromise incremental backups as described in the known issue from VMware.
This problem can occur with all VM Explorer versions. Please update VM Explorer as soon as possible and update also ESX/ESXi 4.0 servers (if present in your infrastructure) as well, because these servers suffer from another problem related to incremental backups as described in VMware KB 1021607 http://kb.vmware.com/kb/1021607
If you do not update VM Explorer, Trilead suggest you do disable incremental backup/replication features and configure full backup/replication instead.